Table 4.
Propensity score weighted, adjusted HRs for periodontitis and total cancer incidence, total cancer death, colorectal cancer incidence and lung cancer incidence, by lifecourse SES
| High SES | Low SES | ||||||||||||
| All Cancer Incidence | Cases | Person-years | HR* | 95% CI | p | All Cancer Incidence | Cases | Person-years | HR* | 95% CI | p | ||
| Periodontitis (CDC-AAP) | Periodontitis (CDC-AAP) | ||||||||||||
| No/mild | 335 | 25847 | 1 | No/mild | 114 | 6744 | 1 | ||||||
| Moderate | 410 | 24552 | 1.08 | 0.93 | 1.25 | 0.34 | Moderate | 150 | 7939 | 0.91 | 0.70 | 1.19 | 0.49 |
| Severe | 196 | 9384 | 1.18 | 0.98 | 1.42 | 0.08 | Severe | 96 | 4682 | 0.89 | 0.65 | 1.20 | 0.44 |
| Ptrend | 0.08 | Ptrend | |||||||||||
| Edentulism | 120 | 5860 | 1.21 | 0.96 | 1.52 | 0.10 | Edentulism | 227 | 10588 | 1.06 | 0.82 | 1.37 | 0.65 |
| Periodontitis (ARIC) | Periodontitis (ARIC) | ||||||||||||
| No/mild | 362 | 28462 | 1.00 | No/mild | 89 | 5975 | 1.00 | ||||||
| Moderate | 347 | 21131 | 1.13 | 0.97 | 1.32 | 0.12 | Moderate | 120 | 6261 | 1.28 | 0.92 | 1.77 | 0.14 |
| Severe | 232 | 10190 | 1.25 | 1.04 | 1.50 | 0.02 | Severe | 151 | 7129 | 1.12 | 0.84 | 1.51 | 0.44 |
| Ptrend | 0.02 | Ptrend | 0.51 | ||||||||||
| Edentulism | 120 | 5860 | 1.22 | 0.98 | 1.53 | 0.08 | Edentulism | 227 | 10588 | 1.29 | 0.98 | 1.71 | 0.07 |
| All Cancer Death | Cases | Person-years | HR* | 95% CI | p | All Cancer Death | Cases | Person-years | HR* | 95% CI | p | ||
| Periodontitis (CDC-AAP) | Periodontitis (CDC-AAP) | ||||||||||||
| No/mild | 77 | 27909 | 1.00 | No/mild | 40 | 7442 | 1 | ||||||
| Moderate | 123 | 26915 | 1.22 | 0.91 | 1.64 | 0.19 | Moderate | 57 | 8651 | 0.95 | 0.61 | 1.48 | 0.81 |
| Severe | 63 | 10333 | 1.38 | 0.98 | 1.96 | 0.07 | Severe | 38 | 5143 | 0.98 | 0.61 | 1.58 | 0.94 |
| Ptrend | 0.06 | Ptrend | 0.92 | ||||||||||
| Edentulism | 51 | 6343 | 1.57 | 1.05 | 2.33 | 0.03 | Edentulism | 98 | 11652 | 1.35 | 0.90 | 2.02 | 0.15 |
| Periodontitis (ARIC) | Periodontitis (ARIC) | ||||||||||||
| No/mild | 86 | 30692 | 1.00 | No/mild | 31 | 6502 | 1.00 | ||||||
| Moderate | 94 | 23188 | 1.17 | 0.86 | 1.58 | 0.32 | Moderate | 44 | 6910 | 1.13 | 0.66 | 1.94 | 0.65 |
| Severe | 83 | 11276 | 1.40 | 1.01 | 1.94 | 0.04 | Severe | 60 | 7823 | 1.24 | 0.77 | 2.01 | 0.37 |
| Ptrend | 0.04 | Ptrend | 0.37 | ||||||||||
| Edentulism | 51 | 6343 | 1.57 | 1.07 | 2.31 | 0.02 | Edentulism | 98 | 11652 | 1.59 | 1.01 | 2.50 | 0.04 |
| Colorectal Cancer Incidence | Cases | Person-years | HR* | 95% CI | p | Colorectal Cancer Incidence | Cases | Person-years | HR* | 95% CI | p | ||
| Periodontitis (CDC-AAP) | Periodontitis (CDC-AAP) | ||||||||||||
| No/mild | 27 | 25847 | 1 | No/mild | 10 | 6744 | 1.00 | ||||||
| Moderate | 33 | 24552 | 1.19 | 0.69 | 2.03 | 0.54 | Moderate | 13 | 7939 | 1.23 | 0.51 | 2.92 | 0.65 |
| Severe | 21 | 9384 | 1.64 | 0.90 | 2.99 | 0.11 | Severe | 12 | 4682 | 2.21 | 0.87 | 5.61 | 0.09 |
| Ptrend | 0.12 | Ptrend | 0.11 | ||||||||||
| Edentulism | 12 | 5860 | 1.52 | 0.75 | 3.05 | 0.24 | Edentulism | 34 | 10588 | 2.41 | 1.06 | 5.49 | 0.04 |
| Periodontitis (ARIC) | Periodontitis (ARIC) | ||||||||||||
| No/mild | 32 | 28462 | 1 | No/mild | 10 | 5975 | 1.00 | ||||||
| Moderate | 27 | 21131 | 1.18 | 0.67 | 2.06 | 0.57 | Moderate | 6 | 6261 | 0.80 | 0.25 | 2.57 | 0.70 |
| Severe | 22 | 10190 | 1.22 | 0.67 | 2.23 | 0.52 | Severe | 19 | 7129 | 1.60 | 0.65 | 3.95 | 0.30 |
| Ptrend | 0.48 | Ptrend | 0.30 | ||||||||||
| Edentulism | 12 | 5860 | 1.39 | 0.70 | 2.76 | 0.35 | Edentulism | 34 | 10588 | 2.27 | 0.95 | 5.45 | 0.07 |
| Lung Cancer Incidence | Cases | Person-years | HR* | 95% CI | p | Lung Cancer Incidence | Cases | Person-years | HR* | 95% CI | p | ||
| Periodontitis (CDC-AAP) | Periodontitis (CDC-AAP) | ||||||||||||
| No/mild | 31 | 25847 | 1 | No/mild | 6 | 6744 | 1.00 | ||||||
| Moderate | 38 | 24552 | 0.82 | 0.49 | 1.35 | 0.43 | Moderate | 24 | 7939 | 1.99 | 0.80 | 4.97 | 0.14 |
| Severe | 38 | 9384 | 1.72 | 1.03 | 2.88 | 0.04 | Severe | 15 | 4682 | 1.91 | 0.74 | 4.96 | 0.18 |
| Ptrend | 0.05 | Ptrend | 0.18 | ||||||||||
| Edentulism | 31 | 5860 | 1.71 | 0.92 | 3.19 | 0.09 | Edentulism | 43 | 10588 | 2.77 | 1.15 | 6.68 | 0.02 |
| Periodontitis (ARIC) | Periodontitis (ARIC) | ||||||||||||
| No/mild | 28 | 28462 | 1 | No/mild | 6 | 5975 | 1.00 | ||||||
| Moderate | 37 | 21131 | 1.21 | 0.71 | 2.06 | 0.48 | Moderate | 11 | 6261 | 1.15 | 0.37 | 3.57 | 0.81 |
| Severe | 42 | 10190 | 1.66 | 0.97 | 2.85 | 0.07 | Severe | 28 | 7129 | 2.40 | 0.97 | 5.96 | 0.06 |
| Ptrend | 0.07 | Ptrend | 0.04 | ||||||||||
| Edentulism | 31 | 5860 | 1.99 | 1.05 | 3.79 | 0.04 | Edentulism | 43 | 10588 | 3.00 | 1.22 | 7.37 | 0.02 |
All Cox models are adjusted for age, field center by race, education level, smoking status, smoking duration, drinking status, body mass index, diabetes status (diagnosed diabetes, undiagnosed diabetes, at risk for diabetes [reference is normal]), joint terms for sex and HRT use (female nonuser, female user [reference is men]), and edentulism status. The propensity score was generated based on neighborhood income, health insurance status, frequency of routine physical examination, having a dentist, frequency of routine dental visit, last time of dental visit separately for participants with low and high lifecourse SES. The inverse of the propensity score was used as a weight in the Cox model. Confidence interval was generated based on robust sandwich variance.