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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 Sep 19;39(11):2261–2272. doi: 10.1161/ATVBAHA.119.313056

Figure 5. LPAR4 regulates experimental atherosclerosis.

Figure 5.

A) Six - 8-week-old wild-type (WT; closed circle) control or Lpar4−/− (open circles) mice were infected with PCSK9 adeno-associated virus. One week later, they were placed on Western diet for 16- weeks and total plasma cholesterol (mg/dL) (n=7–9/group). B) Left Panel: Representative images of proximal aorta. Right Panel: En face analysis of atherosclerosis (% of arch area) in male and female WT (closed circle) and Lpar4−/− (open circles) mice infected with PCSK9 adeno-associated virus and Western diet fed for 16- weeks (n=7–9/group). C) Oil red-O staining and lesion area (% total aorta in root section; n=7–9/group). D) CD68 immunostaining (n=4/group) and E) SM α-actin staining from aortic root sections of male mice (n=2–5/group).