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. 2019 Oct 24;14(10):e0223863. doi: 10.1371/journal.pone.0223863

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© 2019 Kapica-Topczewska et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — A: Relapse-free survival rate B: Disease-progression-free survival rate progression C: T2-lesion-free survival rate D: Gd+-lesion-free survival rate E: NEDA-3 survival rate. The large confidence interval beyond 48 months observed in B, D and E in second-line treatment was due to algorithm artefact linked to low observation availability. Abbreviations: KM, Kaplan–Meier; INF, interferon beta; GA, glatiramer acetate; FTY, fingolimod; NAT, natalizumab; Gd+, gadolinium enhancement; NEDA-3, no evidence of disease activity.