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. 2019 Oct 24;14(10):e0223952. doi: 10.1371/journal.pone.0223952

Table 5. Sensitivity and specificity of mNGS normalized reads for PCR target viruses.

PPV: positive predictive value, NPV, Negative predictive value.

Cut-off number of reads
0 15 50
Sensitivity 96% (23/24*) 92% (22/24) 83% (20/24)
Specificity 98% (1093/1120) 100% (1118/1120) 100% (1118/1120)
PPV 46% (23/50) 92% (22/24) 91% (20/22)
NPV 100% (1093/1094) 100% (1118/1120) 100% (1118/1122)

*The sample with positive confirmatory OC43 PCR included.