Table 1. Summary of steady-state pharmacokinetics for Maraviroca.
| PK Parameter | Maraviroc alone | Maraviroc + Rifabutin | GMR (90% Cl) |
|---|---|---|---|
| AUC (h*μg/L) | 1026.2 (73.6) | 847.0 (66.6) | 0.83 (0.70–0.97) |
| Cmax (μg/L) | 304.6 (91.1) | 239.8 (96.6) | 0.79 (0.57–1.09) |
| Clast or C12 (μg/L) | 23.3 (45.5) | 16.3 (45.5) | 0.70 (0.59–0.82) |
| Tmax | 1.2 (1.0–4.0) | 2.0 (1.0–5.0) | |
| Cl/F (L/h) | 235.0 (62.2) | 319.8 (62.2) | |
| Vd/F (L) | 1833.6 (132.7) | 1496.3 (85.2) |
a Values shown are geometric means, with the geometric coefficient of variation (%), except for the Tmax value which is a median (min-max). AUC, area under the curve; Cmax, maximum plasma concentration; Clast or C12, minimum concentration at last (12 hour) data point; Tmax, time at which maximum plasma concentration was reached; Cl, clearance; F, bioavailability; Vd, volume of distribution.