Table 2. Summary of the steady-state pharmacokinetics for Rifabutin and 25-O-desacetyl rifabutin (Day 15)^a.

PK parameter	Maraviroc + Rifabutin
Rifabutin
AUC (h*μg/L)	4,221.9 (35.6)
Cmax (μg/L)	542.2 (33.5)
Clast or C24 (μg/L)	71.2 (42.8)
Tmax	5.0 (3.0–5.0)
Cl/F (L/h)	54.7 (39.2)
Vd/F (L)	925.1 (34.6)
25-O-desacetyl rifabutin
AUC (h*μg/L)	331.9 (53.6)
Cmax (μg/L)	42.3 (53.9)
Clast or C24 (μg/L)	5.5 (51.3)
Tmax (h)	5.0 (3.0–6.0)
Cl/F (L/h)	714.2 (52.3)
Vd/F (L)	10,817 (57.8)

^a Values shown are geometric means, with the geometric coefficient of variation (%), except for T_max which is a median (min-max). AUC, area under the curve; C_max, maximum plasma concentration; C_last or C₁₂, minimum concentration at last (24 hour) data point; T_max, time at which maximum plasma concentration was reached; Cl, clearance; F, bioavailability; V_d, volume of distribution.