Fig 5. Connectivity patterns among mesonetworks at different stages of the evolutionary timeline. Mesonetworks are represented by vertices while edge thickness shows the number of enzymes shared.

AAC, Amino acid metabolism; SEC, Biosynthesis of other secondary metabolites; CAR, Carbohydrate metabolism; NRG, Energy metabolism; GLY, Glycan biosynthesis and metabolism; LIP, Lipid metabolism; COF, Metabolism of cofactors and vitamins; POL, Metabolism of terpenoids and polyketides; NUC, Nucleotide metabolism; AA2, Metabolism of other amino acids; XEN, Xenobiotics biodegradation and metabolism.