Table 5.

Methodological quality established according to each QUADAS-2 domain for each single study

	Bias risk	Applicability
Imaging	Study	Patients selection	Test index	Reference standard	Flow and time	Patient selection	Text index	Reference standard
CT	Van den Brekel et al. [13]	?	+	+	?	+	+	+
	Van Cann et al. [9]	+	+	+	?	+	+	+
	Gu et al. [14]	?	+	?	+	+	+	+
	Hanschel et al. [15]	?	+	+	?	?	+	+
MRI	Hendrikx et al. [8]	?	?	?	?	+	+	+
	Gu et al. [14]	?	+	?	+	+	+	+
	Van Cann et. [9]	+	+	?	?	+	+	+
	Kolk et al. [16]	+	+	+	?	+	+	+
	Van den Brekel [13]	?	+	+	?	+	−	+
CBCT	Hendrikx et al. [8]	?	?	?	?	+	+	+
	Hakim et al. [12]	+	+	?	+	+	+	+
PET/CT	Gu et al. [14]	?	+	?	+	+	+	+
SPECT	Van Cann et al. [9]	+	+	+	?	+	+	+
	Hakim et al. [12]	+	+	?	+	+	+	+
	Kolk et al. [16]	?	?	+	?	?	?	+
SPECT/CT	Hakim et al. [12]	+	+	?	+	+	+	+
	Kolk et al. [16]	+	+	+	?	+	+	+
MSCT	Hakim et al. [12]	+	+	?	+	+	+	+
	Kolk et al. [16]	+	+	+	?	+	+	+
OPT	Van den Brekel et al. [13]	?	+	+	?	+	+	+
	Hendrikx et al. [8]	?	?	?	?	+	+	+
	Van Cann et al. [9]	+	−	?	+	+	−	+
	Kolk et al. [16]	+	?	?	?	+	+	+

CT: computed tomography; CBCT: cone beam computed tomography; MRI: magnetic resonance imaging; MSCT: multi-slice computed tomography; N.I.: none information; PR: panoramic radiography; PET: positron emission tomography; SPECT: single-photon emission tomography