Table 4.

Summary of meta-regression and subgroup analysis for prevalence of ACO in the general population

	NO. of studies	Prevalence of ACO (95% CI)	I-square	Meta-Regression P-Value
Region of study				0.994
Europe	12	1.3% (1.0–1.6)	99.1%
North America	9	2.5% (1.9–3.0)	99.1%
East Asia	3	1.4% (0.7–2.0)	99.7%
Year of publication				0.995
≤ 2015	7	1.8% (0.7–2.8)	99.4%
>  2015	20	2.1% (1.4–2.8)	100.0%
Study quality				0.865
Low and Moderate (< 8)	5	2.1% (0.7–3.4)	99.5%
High (≥8)	22	2.0% (1.3–2.6)	100.0%

ACO Asthma-COPD Overlap, COPD Chronic Obstructive Pulmonary Disease, CI Confidence Interval