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. 2019 Sep 23;8(10):738–747. doi: 10.1002/psp4.12461

Table 2.

Estimated parameters to predict in vivo non‐specific interaction‐related clearance from affinity‐capture self‐interaction nanoparticle spectroscopy scores

Parameter Tg32 mouse Human
PS_a 0.739 1.81
PS_b −0.0409 −0.262
C mem (μM) 18.5
kint_PS (1/hour) 0.290 0.0380

C mem, cell membrane site density that can bind to mAb; kint_PS, internalization rate of membrane‐bound mAb due to non‐specific interactions; PS_a, empirical parameter a to scale an AC‐SINS score to a binding equilibrium constant; PS_b, empirical parameter b to scale an AC‐SINS score to a binding equilibrium constant.