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. 2019 Oct 18;7:228. doi: 10.3389/fcell.2019.00228

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Copyright © 2019 Sweta, Dudnakova, Sudheer, Baker and Bhushan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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lncRNAs regulate myogenesis at different stages. During myogenesis, myoblast cells proliferate and differentiate into myocytes that fuse together to form multinucleate myotubes. The proliferative and differentiation stages of myogenesis are regulated by several lncRNAs. (A) lncRNAs regulating the myoblast proliferation by activating downstream cell cycle genes. (B) lncRNAs expression and function during cell cycle exit and differentiation to form myotubes. (C) MyoD activated lncRNAs regulate other myogenic factors including MyoD and MyoG to form a complex MyoD–lncRNA–miRNA–mRNA regulatory network during differentiation of myoblasts. (D) Examples of lncRNA expressed and regulating various skeletal muscle disorders.