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. 2019 Oct 18;9:1054. doi: 10.3389/fonc.2019.01054

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Copyright © 2019 Huang, Wu, Zheng, Shao and Lv.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protein-protein network (PPI) based on the DEmRNAs with a combined score was >0.90. (A) 31 hug genes were listed because the degree was >25 in the PPI network. (B) Module analysis of DEmRNA enrolled in PPI network with the criterion cut. Height = 0.8, min size = 10. Same color means it belongs to the same module. And 3 modules were visualized in Cytoscape (C–E). The connection between the nodes indicates the potential interaction between different mRNA, and red represents the hub gene in the PPI network. Meanwhile, GO and KEGG analysis of 3 modules was performed in DAVID (Tables 1–3).