Figure 6.

Dynamics of viral subpopulations, produced by MDCK.SUS2 cells infected by A/PR/8/34-delS1(1) in a parallel continuous bioreactor system at RT 22 h, were fitted using different models. Experimental data (open circles) and four model fits (various lines) are shown for (A) TCID₅₀ titer representing infectious virions of (B) the FL S1-containing virions as well as the sum of all viral subpopulations as log HA units (C) and DI S1-containing virions (D). Every subfigure shows the four model fits, using Model 1 containing all parameters (gray solid line), Model 2 with kdvit = kvdt = 0 (black dotted line), Model 3 with kvi = kvidi (gray dashed line) or Model 4 with kvi = kvidi and kdvit = kvdt = 0 (line of black circles). For the sake of simplicity only every 2^nd data point is shown for the qPCR-based data (B,D). For both experiment and model simulations, the continuous culture was started 23.4 h p.i.