Table 2.
Parameterization and objective function value obtained by fitting different models for the production of A/PR/8/34-delS1(1) by MDCK.SUS2 cells in a parallel continuous bioreactor system at residence time 22 h.
| Parameters | Model 1, all parameters | Model 2, kdvit = kvdt = 0 | Model 3, kvi = kvidi | Model 4, kdvit = kvdt = 0 and kvi = kvidi |
|---|---|---|---|---|
| kvi | 1.59·10−7 | 1.59·10−7 | 4.58·10−9 | 4.58·10−9 |
| kvidi | 2.32·10−10 | 2.33·10−10 | kvi | kvi |
| kcdv | 0.008 | 0.008 | 0.009 | 0.009 |
| μvi | 2.51 | 2.50 | 105 | 104 |
| μvddiC | 203 | 203 | 168 | 168 |
| μvddiS | 1.00·10−5 | 1.15·10−5 | 0.01 | 0.01 |
| μvdC | 4.91·10−16 | 3.13·10−16 | 2.11·10−13 | 2.82·10−13 |
| μvdS | 120 | 120 | 439 | 441 |
| kdvit | 1.58·10−7 | 0 | 1.58·10−4 | 0 |
| kvdt | 3.82·10−27 | 0 | 6.30·10−26 | 0 |
| Objective function value# | 8.50 | 8.49 | 7.99 | 8.00 |
#
Objective function values are the normalized least squared prediction errors of the state variables of all cells Cellstotal, fully infectious STVs VS, replication-incompetent DIPs Vddi, and non-infectious FL S1-containing virions Vd.