Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 18;10:1232. doi: 10.3389/fphar.2019.01232

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Climent and Plana

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic representation of dasatinib mediated mechanisms that could interfere with HIV-1 infection. (1) Inhibition of SAMHD1 phosphorylation, maintaining its intrinsic antiviral activity; (2) inhibition of mass activation, establishment of viral reservoirs, depletion of CD4⁺ T cells, and reduction of infected cells that carry the pro-viral DNA of HIV-1; (3) inhibition of inflammation and reduction in senescence; (4) potentiation of cytotoxic activity mediated by memory NK cells and T lymphocytes against HIV; (5) increase of immune effector cells such as cytotoxic LGLs by reducing levels of Tregs and M-MDSC, which are suppressor cells. Adapted from Coiras et al. (2017).