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. 2019 Oct 18;10:1189. doi: 10.3389/fphar.2019.01189

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Copyright © 2019 Fan, Men, Wang, Shen, Wang, Ye, Luo and Yang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MP pretreatment attenuates hepatocyte apoptosis and autophagy in ConA−induced EAH, partially through the Akt/mTOR signaling pathway. (A) TUNEL staining indicated apoptotic hepatocytes in the three groups after ConA injection (original magnification, ×400). (B) Protein expression of Bcl−2, Bax, and cleaved caspase−3 in liver tissues. (C) Immunohistochemistry was used to detect Bcl−2 and Bax levels in liver tissues (original magnification, ×200). ConA, concanavalin A; MP, methylprednisolone; NC, normal control; EAH, experimental autoimmune hepatitis; IOD, integrated optical density. **P < 0.01 vs. NC group; ^#P < 0.05 vs. ConA group (20 mg/kg); ^##P < 0.01 vs. ConA group (20 mg/kg).