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. 2019 Oct 24;9:14914. doi: 10.1038/s41598-019-50612-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Levels of state mindfulness (Toronto Mindfulness Scale total score) and (B) meditation depth (Meditation Depth Questionnaire total score) over the course of the retreat. Data are means ± 1 SEM (standard error of the mean). The asterisk indicates a significant difference between psilocybin and placebo groups on day 4, when the drug was administered (*p < 0.01). Both state mindfulness and meditation depth increased between day 1 and day 5 (mindfulness, mean ± SEM: 29.61 ± 1.18 and 32.42 ± 1.36 on day 1 and day 5, respectively, p < 0.05; meditation depth, mean ± SEM: 63.0 ± 3.31 and 77.7 ± 3.74 on day 1 and day 5, respectively, p < 0.001). The p-values have been adjusted for multiple comparisons within this analysis.