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. 2019 Oct 24;10:4846. doi: 10.1038/s41467-019-12802-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Comparison of Top2 activity in S. cerevisiae and human cells. Topological stress arising within chromosomes is primarily resolved by Top2 in IGRs in the compact S. cerevisiae genome. By contrast, in human cells, TOP2 activity is located around the binding sites of CTCF—a nuclear organising factor that both patterns cohesin dependent loop extrusion and causes local nucleosomal ordering—and also preferentially towards the 5′ end of genes, where it correlates with local transcriptional activity