Fig. 6. Chaetocin inhibits the growth of HGC-27 cell xenografts.

Nude mice were subcutaneously inoculated with HGC-27 and then treated with vehicle or chaetocin (0.5 mg/kg) for 24 d. a and b tumor volume, and c tumor weight of HGC-27 GC cell xenografts in nude mice. d Body weight of the mice. e Levels of p-AKT, AKT and pro-caspase-3 in tumor tissues were detected by western blot (HGC-27 vehicle group: 3, 5, 6; HGC-27 chaetocin-treated group: 12, 13, 16). f TRXR activity in tumor tissues was determined by DTNB assay. g Ki-67 expression in tumor tissues was detected using immunohistochemistry. Scale bar: 100 μm. Results were shown as mean ± SD of six mice in each group. *P < 0.05, **P < 0.01, vs. control group