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. 2019 Oct 15;11:29. doi: 10.3389/fnsyn.2019.00029

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Copyright © 2019 Barros-Zulaica, Rahmon, Chindemi, Perin, Markram, Muller and Ramaswamy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Noise calibration. (A) Example of an in vitro single protocol repetition (top). Zoom over 400 ms segment used to compute the parameters for noise calibration (bottom). (B) Distribution of σ (up) and τ (bottom). σ was computed as the standard deviation of the voltage segment. τ was computed by fitting the voltage segment autocorrelation to an exponential. The distributions show the mean values for the 33 in vitro connections. (C) (up) Single in silico trace without noise, (middle) OU-process generated to be added to the single in silico trace and (bottom) the noisy single protocol repetition that is the result of adding the previous two traces.