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. 2019 Oct 15;11:29. doi: 10.3389/fnsyn.2019.00029

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Copyright © 2019 Barros-Zulaica, Rahmon, Chindemi, Perin, Markram, Muller and Ramaswamy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NRRP computation. (A) Illustration showing one synaptic connection releasing neuro transmitters from only one vesicle (top) and the same synaptic connection releasing neurotransmitters from twenty vesicles (bottom). (B) The corresponding effect of releasing neurotransmitters from one (top) or from twenty (bottom) vesicles reflected on the variability and shape of the in silico traces. The mean voltage traces are painted in blue while each protocol repetition is represented in gray. (C) Diagram showing the effect of N_RRP over the CV. (D) Mean CV profile for the in vitro (red) and all the in silico connections with different N_RRP values. (E) Diagram explaining the mean square distance computation. (F) N_RRP against error, showed a clear minimum around the value obtained for this specific connection.