Table 1.
Gene | SNP | MAF (%) | Model | CONTR | CASE | OR | 95%CI | p | |
---|---|---|---|---|---|---|---|---|---|
Contr | Case | ||||||||
APOPTOSIS AND NECROPTOSIS | |||||||||
TNF | rs1800630 | 15.7 | 26.2 | add | 61/327 | 117/329 | 1.90 | [1.34–2.70] | 0.0003 |
6p21.33 | C>a | rec | 7/187 | 14/209 | 1.79 | [0.70–4.54] | 0.2214 | ||
Promoter | dom | 54/140 | 103/120 | 2.24 | [1.49–3.38] | 0.0001 | |||
TRAF2 | rs10781522 | 49.2 | 38 | add | 191/197 | 171/279 | 0.64 | [0.48–0.84] | 0.0014 |
9q34.3 | g>A | rec | 47/147 | 34/191 | 0.58 | [0.35–0.95] | 0.0305 | ||
Intron 9 | dom | 144/50 | 137/88 | 0.52 | [0.34–0.79] | 0.0024 | |||
APOPTOSIS | |||||||||
PAK2 | rs9325377 | 49.5 | 42 | add | 196/192 | 190/162 | 0.72 | [0.54–0.94] | 0.0173 |
3q29 | a>G | rec | 55/139 | 36/190 | 0.47 | [0.29–0.77] | 0.0023 | ||
Intron 1 | dom | 141/53 | 154/72 | 0.81 | [0.53–1.25] | 0.3449 | |||
CD36 | rs4112274 | 7.51 | 15.27 | add | 29/357 | 69/383 | 2.14 | [1.33–3.44] | 0.0015 |
7q21.11 | C>t | rec | 1/192 | 5/221 | 3.92 | [0.45–34.2] | 0.2169 | ||
Intron 3 | dom | 28/165 | 64/162 | 2.23 | [1.34–3.68] | 0.0018 | |||
IMMUNOGENIC | |||||||||
EIF2AK3 | rs10167879 | 17.6 | 9.9 | add | 67/313 | 43/393 | 0.48 | [0.31–0.73] | 0.0007 |
2p11.2 | C>t | rec | 5/185 | 4/214 | 0.62 | [0.16–2.40] | 0.4940 | ||
Intron 14 | dom | 62/128 | 39/179 | 0.41 | [0.26–0.66] | 0.0002 | |||
SIRPA | rs6075340 | 33.5 | 42.1 | add | 130/258 | 191/263 | 1.50 | [1.13–2.00] | 0.0055 |
20p13 | a>G | rec | 17/177 | 47/180 | 2.75 | [1.51–4.98] | 0.0009 | ||
Intron 2 | dom | 113/81 | 144/83 | 1.35 | [0.90–2.02] | 0.1449 | |||
CD47 | rs12695175 | 11.4 | 17.9 | add | 44/342 | 81/371 | 1.77 | [1.20–2.63] | 0.0043 |
3q13.12 | T>g | rec | 4/189 | 10/216 | 2.23 | [0.68–7.30] | 0.1850 | ||
Intron 6 | dom | 40/153 | 71/155 | 1.95 | [1.23–3.07] | 0.0041 | |||
NECROSIS | |||||||||
RAPGEF3 | rs10747521 | 40.1 | 36.7 | add | 155/231 | 165/285 | 0.81 | [0.61–1.1] | 0.1676 |
12q13.11 | a>G | rec | 36/157 | 23/202 | 0.42 | [0.23–0.76] | 0.0040 | ||
Intron 1 | dom | 155/231 | 165/285 | 1.03 | [0.20–0.69] | 0.8837 | |||
PARTHANATOS | |||||||||
HK1 | rs7072268 | 43.0 | 53.1 | add | 167/221 | 241/213 | 1.48 | [1.13–1.94] | 0.0045 |
10q22.1 | t>C | rec | 37/157 | 70/157 | 1.57 | [1.02–2.42] | 0.0412 | ||
Intron 5 | dom | 130/64 | 171/56 | 1.87 | [1.18–2.95] | 0.0076 | |||
PYROPTOSIS | |||||||||
PRKN | rs9355950 | 34.3 | 22.9 | add | 133/255 | 104/350 | 0.57 | [0.42–0.78] | 0.0004 |
6q26 | T>c | rec | 25/169 | 11/216 | 0.35 | [0.16–0.73] | 0.00502 | ||
Intron 4 | dom | 108/86 | 93/134 | 0.55 | [0.37–0.81] | 0.0024 |
Logistic regression association tests were done with allele frequencies (“add”), frequency of homozygotes for the minor allele (“rec”- recessive model), and summed frequencies of heterozygotes and homozygotes for the minor allele (“dom”—dominant model). The minor alleles in our sample are given in lowercase; they are the reference for the associations. In bold, significant associations (p < 0.005). SNP, single nucleotide polymorphism; MAF, minor allele frequency; CONTR, controls; CASE, cases; Model, association tests; OR, odds ratio; CI, confidence interval; TNF, tumor necrosis factor alpha; TRAF2, TNF receptor associated factor 2; PAK2, p21 (RAC1) activated kinase 2; CD36, CD36 molecule; EIF2AK3, eukaryotic translation initiation factor 2 alpha kinase 3 (also known as PERK); SIRPA, signal regulatory protein alpha; CD47, CD47 molecule; RAPGEF3, Rap guanine nucleotide exchange factor 3 (also known as EPAC); HK1, hexokinase 1; PRKN, parkin RBR E3 ubiquitin protein ligase (also known as PARK2).