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. 2019 Oct 18;10:2236. doi: 10.3389/fimmu.2019.02236

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Copyright © 2019 Meda Spaccamela, Valencia, Pastukhov, Duppenthaler, Dettmer, Erb, Steiner, Hillinger, Speckmann, Ehl, Reichenbach and Siler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of IL-18 and IFN-γ in inflamed lymph node tissue of a CGD patient at 6 weeks of inflammation. (A) Merged DAPI (blue), IL-18 (green)/CD68 (red) double immunofluorescence staining. IL-18 signal (FITC, Alexa488) colocalized with CD68 (Cy3) on tissue macrophages. Single stainings are in Figure S1. (B) Immunohistochemical detection of IFN-γ.