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. 2019 Oct 18;10:2384. doi: 10.3389/fimmu.2019.02384

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Copyright © 2019 Leite Pereira, Bitoun, Paoletti, Nocturne, Marcos Lopez, Cosma, Le Grand, Mariette and Tchitchek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of CD11a^high Granzyme B^high T-cell subpopulation. All cells contained in T-cell clusters from SPADE analysis were computationally isolated and represented using viSNE, based on the expression of CD11a, CCR5, and Granzyme B. (A) viSNE representation showing three phenotypic areas delineated according to the localization of cells from RA patients (Areas 1 and 2) and healthy donors (Area 3). (B) viSNE maps representing the distribution of T-cells according to their expression of CD11a, CCR5, and Granzyme B. (C) viSNE maps representing the levels of CD11a and Granzyme B expressed by T-cells. (D) RA-patients were split into two groups, called group A and group B. viSNE maps representing the distribution of T-cells, according to their expression of CD11a, CCR5, and Granzyme B, for healthy donors and each group of RA patients.