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. 2019 Oct 18;10:705. doi: 10.3389/fendo.2019.00705

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Copyright © 2019 Zhang, Hou, Wen, Li, Qi, Li and Tao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of amino acid sequences between LmMC4R and MC4Rs from other species (A) and phylogenetic tree of MC4R proteins (B). In (A), amino acids in shaded boxes indicate putative TMD 1-7, the most conserved residues in each TMD are underlined. In (B), trees were constructed using the neighbor-joining (NJ) method. Box shows LmMC4R. GenBank accession numbers: alligator (XP_006025279.1); Atlantic salmon (XP_014036044.1); cat (BBD19891.1); chicken (NP_001026685.1); chimpanzee (PNI69802.1); coho salmon (XP_020349696.1); common carp (CBX89936.1); dog (NP_001074193.1); European river lamprey MCRa (ABB36647.1); European river lamprey MCRb (ABB36648.1); European seabass (CBN82190.1); goldfish (CAD58853.1); horse (XP_001489706.1); human (NP_005903.2); mouse (NP_058673.2); Northern snakehead (AMM02541.1); rat (NP_037231.1); turtle (XP_024059247.1); Wuchang bream (AWA81516.1); zebrafish (NP_775385.1).