Table 2.

Summary of multidimensional external validation results based on multiple databases.

Database	AXIN2		CASP9		CGN		RASSF8-AS1		MIR4458HG		Results
	Cancer	Normal	Cancer	Normal	Cancer	Normal	Cancer	Normal	Cancer	Normal
Oncomine	↑	↓	↑	↓	-	-	-	-	-	-	According to 17 analyses, AXIN was highly expressed in various tumors compared to normal tissue, while CASP9 was highly expressed only in medulloblastoma across two analyses (Figure S1).
cBioPortal	↑	↓	↑	↓	↑	↓	↑	↓	↑	↓	AXIN2, CASP9, CGN, RASSF8-AS1, and MIR4458HG were highly expressed in mesothelioma compared to some other types of cancer (Figure S2).
CCLE	-	-	-	-	-	-	-	-	-	-	AXIN2, CASP9, CGN, RASSF8-AS1, and MIR4458HG were expressed in various mesothelioma cell lines but not in immune cells biomarkers (Figure S3).
UALCAN	-	-	-	-	-	-	-	-	-	-	High expression of CGN indicated higher survival probability (Figure S6).
PROGgeneV2	-	-	-	-	-	-	-	-	-	-	High expression of AXIN2, CASP9, and CGN indicated higher overall survival (Figure S4).
STRING	-	-	-	-	-	-	-	-	-	-	AXIN2, CASP9, and CGN had significant Protein-Protein interaction network (Figure S5).

“↑” was defined as a significantly upregulated gene; “↓” was defined as a significantly downregulated gene; “-” was defined as a gene with no significant difference in expression. CCLE, Cancer Cell Line Encyclopedia.