Table 1. High-risk Genes According to 23-Gene Molecular Test.
| Gene | Covered Region (Human Reference Genome Version) |
|---|---|
| AKT1 | aa 17-18 |
| APC | aa 178-291 and 312-1594 with splice sites |
| AXIN1 | aa 1-688 and 731-865 with splice sites |
| BRAF | aa 594-606 and 439-478 |
| CDKN2A | Full with splice sites |
| CTNNB1 | aa 6-60 |
| DNMT3A | aa 881-883 |
| EGFR | Exons 18, 19, 20, 21 |
| EIF1AX | aa 1-6, 35-86, and 115-147 |
| GNAS | aa 201-203 and 226-227 |
| HRAS | aa 10-14, 60-62, and 146 |
| IDH1 | aa 67-71 and 123-134 |
| KRAS | aa 10-14, 60-62, and 146 |
| NDUFA13 | Full with splice sites |
| NRAS | aa 10-14, 60-62, and 146 |
| PIK3CA | aa 520-554 and 980-1069 |
| PTEN | Full with splice sites |
| RET | aa 883, 918, and 588-636 |
| SMAD4 | aa 36-552 with splice sites |
| TERT | promoter chr5: 1295228 and 1295250 |
| TP53 | aa 26-393 with splice sites |
| TSHR | Full with splice sites |
| VHL | Full with splice sites |
Abbreviation: aa, amino acid residue numbers.