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. 2019 Oct 24;137(12):1444–1448. doi: 10.1001/jamaophthalmol.2019.4237

Figure 1. Multinodular Extensive Conjunctival Melanoma (CM) of the Left Eye .

Figure 1.

A and B, The patient presented with a CM that involved the upper and lower eyelids and bulbar conjunctiva (eTable in the Supplement, case 5). Given the extent of the disease, an incisional biopsy was done for diagnosis prior to planned exenteration. The tumor was found to harbor the BRAF V600E mutation and, following discussions with the medical oncologist and patient, neoadjuvant therapy with systemic BRAF and MEK inhibitors was started. C and D, After 3 months of therapy, the conjunctival melanoma regressed.