Table 3.

Analytical data counts and acquisition time of liver incubation systems.

Ion(M/Z value)	Retention time (min)	BR no incubation	BR incubation	BR+Liver microsome	BR+Liver microsome + NADPH	BR+Liver microsome + NADPH + furafylline	P
301*	7.937 ± 0.007	15.982 ± 1.237	17.809 ± 0.962	15.881 ± 0.635	16.811 ± 1.500	16.444 ± 0.672	0.144
	12.570 ± 0.154	17.112 ± 4.680	17.779 ± 4.310	15.290 ± 1.060	13.068 ± 1.425	12.426 ± 1.423	0.131
315*	5.182 ± 0.005	0.848 ± 0.093	0.810 ± 0.040	0.770 ± 0.083	0.782 ± 0.115	0.813 ± 0.076	0.791
	12.618 ± 0.143	2.581 ± 0.007	2.844 ± 0.348	3.722 ± 2.333	2.138 ± 0.383	4.059 ± 1.640	0.315
333*	0.422 ± 0.002	5.230 ± 0.454	5.830 ± 0.278	4.746 ± 0.052#	0	0	0.000
	12.731 ± 0.084	18.208 ± 0.960	17.052 ± 1.450	24.690 ± 9.360	16.700 ± 0.970	15.912 ± 0.989	0.120
Bilirubin*	11.383 ± 0.009	2.471 ± 0.430	2.117 ± 0.354	1.820 ± 1.119	2.055 ± 0.291	2.165 ± 0.883	0.844
	11.070 ± 0.030	1.409 ± 0.154	1.015 ± 0.376	0.400 ± 0.200 &#	0.510± 0.082 &	0.565 ± 0.100 &	0.000
Biliverdin*	11.383 ± 0.008	0.094± 0.018	0.066 ± 0.014	0.055 ± 0.029	0.095 ± 0.017	0.111 ± 0.028	0.141
	4.908 ± 0.007	0.062 ± 0.018	0.052 ± 0.013	0.068 ± 0.048	0.098 ± 0.009	0.088 ± 0.019	0.035

The retention time and relative molecular intensity of liver microsomes. There is no statistical difference among these groups.

*: area of BR/area of IS; IS, donepezil (DNP, internal standard); BR, bilirubin