Table 4.

Analytical data counts and acquisition time of brain incubation systems.

Ion(M/Z value)	Retentiontime (min)	BR no incubation	BR incubation	BR+Brain microsome	BR+Brain microsome +NADPH	BR+Brain microsome + NADPH + furafylline	P
301*	7.937 ± 0.007	15.982 ± 1.237	17.809 ± 0.962	18.404 ± 3.383	16.264 ± 3.745	19.493 ± 4.904	0.643
	12.570 ± 0.154	17.112 ± 4.680	17.779 ± 4.310	15.561 ± 2.058	17.108 ± 1.257	16.017 ± 4.505	0.942
315*	5.182 ± 0.005	0.848 ± 0.093	0.810 ± 0.040	0.842 ± 0.062	0.832 ± 0.042	0.0842 ± 0.060	0.915
	12.618 ± 0.143	2.581 ± 0.007	2.844 ± 0.348	2.585 ± 0.069	2.728 ± 0.112	2.997 ± 1.142	0.897
333*	0.422 ± 0.002	5.230 ± 0.454	5.830 ± 0.278	5.234 ± 0.372	0	0	0.000
	12.731 ± 0.084	18.208 ± 0.960	17.052 ± 1.450	24.652 ± 11.957	17.005 ± 0.522	17.138 ± 2.554	0.382
Bilirubin*	11.383 ± 0.009	2.471 ± 0.430	2.117 ± 0.354	1.949 ± 0.584	2.270 ± 0.703	2.976 ± 0.668	0.140
	11.070 ± 0.030	1.409 ± 0.154	1.015 ± 0.376	0.533 ± 0.098#	0.581 ± 0.034#	0.557 ± 0.174#	0.001
Biliverdin*	11.383 ± 0.008	0.094± 0.018	0.066 ± 0.014	0.067 ± 0.019	0.092 ± 0.017	0.121 ± 0.028	0.014
	4.908 ± 0.007	0.062 ± 0.018	0.052 ± 0.013	0.057 ± 0.020	0.085 ± 0.021	0.094 ± 0.037	0.148

The retention time and relative molecular intensity of brain microsomes. There is no statistical difference among these groups.

*: area of BR/area of IS; IS, donepezil (DNP, internal standard); BR, bilirubin