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. 2019 Oct 18;13:1098. doi: 10.3389/fnins.2019.01098

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Copyright © 2019 Cheng, Chen, Yue, Zhang, Pei, Cheng, Liu, Xu, Dong and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CLSTN1 shRNA affects dendritic morphology. (A) Representative images of Dil-stained neurons after transfection with CLSTN1 shRNA or CLSTN1 CTR. Each photograph represents a 20-μm-long dendritic segment, n = 12. (B) Categories of spine morphology, mushroom (spines with a large bulbous head; the spine head diameter is at least 1.5 μm and larger than the spine neck diameter); thin (filopodia-like protrusions; diameters of the spine and neck are nearly equal, and spine length is greater than spine width); stubby (short spines without a well-defined spine neck); branched (spines with more than one head). (C–E) Quantifications of dendritic morphology, spine length and spine number. CLSTN1 shRNA affects dendritic morphology. Data are shown as mean ± SD. *p < 0.05, **p < 0.01 compared to CLSTN1 CTR.