Figure 3.
A, Prior to adjusting for multiple comparisons, a significant correlation (ρ = 0.50 p = .036, adj. p = .23) exists between the changes in R1 in the substantia nigra (ΔR1SN) versus the change in Mn exposure at 3 months prior to scan (ΔMn-CEI3M) but no linear relationship. Whereas in (B) there is not only a significant correlation (ρ = 0.66, p = .001, adj. p < .02), but also a linear relationship between the change in thalamic GABA (ΔGABAThal) and ΔMn-CEI3M (β = 14.7, p = .02). C, Depicts a borderline significant correlation (ρ = 0.64, p = .006, adj. p = .05) between the change in toenail concentration (Δ[Mn]Toenail) and the change in Mn exposure at 7–12 months prior to scan (ΔMn-CEI7–12M).