Table 2.
Demographic Adjusted Average Level and Rate of Change in Global Cognition Among AAs and EAsa
| AAs Only |
EAs Only |
|
|---|---|---|
| APOE Genotype | (N = 3495) | (N = 2312) |
| Average Level of Baseline Cognition | ||
| ε3/ε3 | 0.118 (0.017)b | 0.565 (0.018)b |
| ε2/ε2 vs ε3/ε3 | −0.101 (0.098) | 0.093 (0.152) |
| ε2/ε3 vs ε3/ε3 | 0.045 (0.029) | 0.025 (0.036) |
| ε2/ε4 vs ε3/ε3 | −0.007 (0.048) | −0.008 (0.081) |
| ε3/ε4 vs ε3/ε3 | −0.018 (0.023) | −0.098 (0.029) |
| ε4/ε4 vs ε3/ε3 | −0.185 (0.049)b | −0.315 (0.091)b |
| Rate of Decline in Cognition | ||
| ε3/ε3 | 0.046 (0.003)b | 0.059 (0.003)b |
| ε2/ε2 vs ε3/ε3 | −0.032 (0.013)c | −0.010 (0.027) |
| ε2/ε3 vs ε3/ε3 | −0.004 (0.004) | −0.010 (0.006) |
| ε2/ε4 vs ε3/ε3 | 0.009 (0.006) | 0.026 (0.013)d |
| ε3/ε4 vs ε3/ε3 | 0.018 (0.003)b | 0.031 (0.005)b |
| ε4/ε4 vs ε3/ε3 | 0.045 (0.009)b | 0.059 (0.013)b |
Abbreviations: AA, African American; APOE, apolipoprotein E; EA, European American.
a
Data are given coefficient (SE). Race-specific models adjusted for main effects of age, sex, and education, and interaction of linear time since baseline with each of the demographic variable. Each of the race-specific models also consist of five indicator variables for APOE genotypes, with APOE ε3ε3 as the reference category.
b
P < .0001.
c
P < .05.
d
P < .001.