. Author manuscript; available in PMC: 2019 Oct 25.

Published in final edited form as: J Am Geriatr Soc. 2018 Dec 24;67(4):734–740. doi: 10.1111/jgs.15727

Table 3.

Average Level and Rate of Decline in Global Cognition, by Age Groups^a

	Aged <75 y	Aged >75 y
APOE Genotype	(N = 4158)	(N = 1651)	P_Interaction

Average Level of Baseline Cognition
ε3/ε3	0.509 (0.023)^b	0.713 (0.041)^b	<.0001
ε2/ε2 vs ε3/ε3	−0.036 (0.088)	−0.098 (0.184)	.47
ε2/ε3 vs ε3/ε3	0.027 (0.024)	0.042 (0.051)	.92
ε2/ε4 vs ε3/ε3	0.016 (0.042)	−0.127 (0.103)	.11
ε3/ε4 vs ε3/ε3	−0.014 (0.019)^c	−0.141 (0.043)^c	.011
ε4/ε4 vs ε3/ε3	−0.164 (0.043)^b	−0.469 (0.054)^b	.002
Rate of Decline in Cognition
ε3/ε3	0.040 (0.003)^b	0.053 (0.007)^b	<.0001
ε2/ε2 vs ε3/ε3	−0.028 (0.013)^d	−0.030 (0.030)	.89
ε2/ε3 vs ε3/ε3	−0.004 (0.003)	−0.014 (0.009)	.043
ε2/ε4 vs ε3/ε3	0.019 (0.006)^d	−0.023 (0.019)	.016
ε3/ε4 vs ε3/ε3	0.019 (0.003)^b	0.038 (0.008)^b	.021
ε4/ε4 vs ε3/ε3	0.046 (0.006)^b	0.059 (0.023)^d	.87

Abbreviation: APOE, apolipoprotein E.

Data are given as coefficient (SE). The model for interaction test included main effects of age, sex, race, and education, and interaction of linear time since baseline with each of the demographic variables. Age-specific models adjusted for main effects of age, sex, and education, and interaction of linear time since baseline with each of the demographic variables.

P < .0001.

P < .001.

P < .05.