. Author manuscript; available in PMC: 2019 Oct 25.

Published in final edited form as: J Am Geriatr Soc. 2018 Dec 24;67(4):734–740. doi: 10.1111/jgs.15727

Table 4.

Average Level and Rate of Decline in Individual Cognitive Tests of Episodic Memory, Executive Function, and MMSE in the CHAP Biracial Sample^a

APOE Genotype	Episodic Memory	Executive Function	MMSE

Average Level of Baseline Cognition
ε3/ε3	0.435 (0.019)^b	0.706 (0.021)^b	0.379 (0.016)^b
ε2/ε2 vs ε3/ε3	−0.073 (0.104)	−0.084 (0.100)	−0.019 (0.085)
ε2/ε3 vs ε3/ε3	0.021 (0.028)	0.059 (0.027)^c	0.043 (0.023)
ε2/ε4 vs ε3/ε3	−0.009 (0.052)	−0.012 (0.049)	−0.018 (0.042)
ε3/ε4 vs ε3/ε3	−0.078 (0.022)^d	−0.016 (0.021)	−0.022 (0.018)
ε4/ε4 vs ε3/ε3	−0.275 (0.054)^b	−0.148 (0.054)^c	−0.176 (0.044)^b
Rate of Decline in Cognition
ε3/ε3	0.033 (0.003)^b	0.056 (0.002)^b	0.054 (0.003)^b
ε2/ε2 vs ε3/ε3	−0.050 (0.015)^d	−0.001 (0.012)	−0.003 (0.014)
ε2/ε3 vs ε3/ε3	−0.008 (0.004)^c	0.002 (0.003)	−0.008 (0.004)^c
ε2/ε4 vs ε3/ε3	0.016 (0.007)^c	0.016 (0.006)^d	0.003 (0.007)
ε3/ε4 vs ε3/ε3	0.019 (0.003)^b	0.016 (0.003)^b	0.024 (0.003)^b
ε4/ε4 vs ε3/ε3	0.046 (0.008)^b	0.034 (0.006)^b	0.058 (0.007)^b

Abbreviations: APOE, apolipoprotein E; CHAP, Chicago Health and Aging Project; MMSE, Mini-Mental State Examination.

Data are given as coefficient (SE). Models adjusting for main effects of age, sex, race, and education, and interaction of linear time since baseline with each of the demographic variables.

P < .0001.

P < .05.

P < .001.