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. Author manuscript; available in PMC: 2019 Oct 25.
Published in final edited form as: Cell Rep. 2014 Jul 4;8(1):59–65. doi: 10.1016/j.celrep.2014.04.058

Figure 4. Scheme of Eukaryotic Translation Termination and Ribosome Recycling.

Figure 4.

For termination, the stop codon in the A site is recognized by the eRF1-eRF3-GTP ternary complex. eRF3 dissociates after GTP hydrolysis and allows the central domain of eRF1 to swing to the PTC. Proper positioning of the GGQ motif in the central domain of eRF1 may already allow peptide release, resulting in a termination complex with the deacyl-tRNA in the P state or P/E hybrid state. Alternatively, the active conformation of eRF1 in the pretermination complex is stabilized after binding of ABCE1. This stimulates peptide release while the NTD of eRF1 is delocalized, thus decoupling decoding from peptide release. Independent of the termination mechanism, ABCE1 together with eRF1 functions in concert to dissociate the ribosome into small and large subunits.