Age at study entry, median (range) |
42 (16–67) |
Gender, female, n (%) |
20 (50) |
Phase of chronic myeloid leukemia at HCT, n (%) |
|
Chronic |
27 (67.5) |
Accelerated |
10 (25) |
Blast crisis in complete hematologic remission |
3 (7.5) |
Donor type, n (%) |
|
Matched related |
18 (45) |
Matched unrelated |
13 (32.5) |
Mismatched related |
4 (10) |
Mismatched unrelated |
5 (12.5) |
Graft source, n (%) |
|
Bone Marrow |
38 (95) |
Peripheral blood stem cells |
2 (5) |
Conditioning regimen, n (%) |
|
Total body irradiation + cyclophosphamide |
22 (55) |
Busulfan + cyclophosphamide |
18 (45) |
GvHD prophylactic regimen, n (%) |
|
Methotrexate + calcineurin inhibitor |
40 (100) |
Anti-thymocyte globulin |
4 (10) |
Months from HCT to molecular relapse, median (range) |
6.3 (5.6–13.6) |
Complete cytogenetic remission at enrollment, n (%) |
40 (100) |
Use of TKIs prior to enrollment, n (%) |
0 |
Use of IFN prior to transplant, n (%) |
19 (47.5) |