Table 1.
Parameters | total | Subtype | P-value | ||||
---|---|---|---|---|---|---|---|
EBV | MSI | EMT | p53-ab | p53-wt | |||
Sex | 0.0002 | ||||||
female | 112 | 2 | 13 | 25 | 36 | 36 | |
male | 309 | 30 | 21 | 49 | 147 | 62 | |
Age* | 57.5±0.6 | 56.8±2.0 | 67.8±2.1 | 56.2±1.4 | 59.5±0.9 | 52.8±1.3 | <0.0001 |
WHO | <0.0001 | ||||||
well diff | 32 | 2 | 4 | 0 | 21 | 5 | |
mod diff | 147 | 4 | 16 | 8 | 91 | 28 | |
poorly diff | 147 | 27 | 13 | 27 | 53 | 29 | |
signet ring cell | 73 | 0 | 0 | 28 | 11 | 34 | |
others | 22 | 1 | 1 | 11 | 7 | 2 | |
Lauren | <0.0001 | ||||||
intestinal | 176 | 9 | 18 | 52 | 107 | 31 | |
diffuse | 170 | 14 | 9 | 11 | 42 | 53 | |
mixed | 72 | 9 | 7 | 10 | 32 | 14 | |
undetermined | 3 | 0 | 0 | 0 | 2 | 0 | |
EBV | <0.0001 | ||||||
negative | 381 | 0 | 34 | 72 | 179 | 96 | |
positive | 32 | 32 | 0 | 0 | 0 | 0 | |
MSI | <0.0001 | ||||||
stable | 387 | 32 | 0 | 74 | 183 | 98 | |
unstable | 34 | 0 | 34 | 0 | 0 | 0 | |
E-cadherin | <0.0001 | ||||||
aberrant | 82 | 3 | 5 | 74 | 0 | 0 | |
normal | 331 | 24 | 26 | 0 | 183 | 98 | |
p53 status | |||||||
mutant | 229 | 4 | 14 | 28 | 180 | 0 | <0.0001 |
wildtype | 179 | 23 | 17 | 41 | 0 | 98 | |
T stage** | 0.0037 | ||||||
T1 | 112 | 12 | 5 | 11 | 47 | 37 | |
T2 | 64 | 3 | 11 | 9 | 25 | 16 | |
T3 | 151 | 10 | 15 | 34 | 65 | 27 | |
T4 | 94 | 7 | 3 | 20 | 46 | 18 | |
N stage** | 0.2168 | ||||||
N0 | 176 | 18 | 15 | 25 | 69 | 49 | |
N1 | 58 | 4 | 6 | 7 | 27 | 14 | |
N2 | 58 | 5 | 5 | 12 | 24 | 12 | |
N3 | 129 | 5 | 8 | 30 | 63 | 23 | |
TNM stage** | 0.0110 | ||||||
I | 141 | 13 | 9 | 16 | 57 | 46 | |
II | 94 | 9 | 12 | 17 | 38 | 18 | |
III | 133 | 5 | 12 | 31 | 60 | 25 | |
IV | 53 | 5 | 1 | 10 | 28 | 9 |
p53-wt: p53 wildtype; p53-ab: p53 aberrant
Age is presented as mean ± SEM (standard error of mean)
Based on AJCC seventh edition.