Table 3.

Multivariate analysis of IDO1 and WARS expression

Parameter	Risk Ratio	Lower 95%	Upper 95%	P-value
Age	2.78*	1.31	5.92	0.0079
Subtype				0.1423
EBV/p53-wt+MSI	1.03	0.51	2.07	0.9324
p53-ab+EMT/EBV	1.42	0.71	2.83	0.3198
TNM stage				<0.0001
T2/T1	1.55	0.73	3.29	0.2544
T3/T2	3.34	1.85	6.03	<0.0001
T4/T3	2.15	1.56	2.97	<0.0001
IDO1-t pos/neg	1.20	0.86	1.65	0.2816
IDO1-s pos/neg	1.11	0.81	1.53	0.5069
WARS-t pos/neg	1.41	0.98	2.04	0.0663
WARS-s pos/neg	0.82	0.55	1.23	0.3386

^*Per change in regressor over entire range