Table 1. Comparison of the LD50 doses for chemotherapeutics on all cell lines.

Table summarizes the LD50 doses for all chemotherapeutics on all four cell lines tested. Composite LD50 doses for all compounds affecting DNA replication and repair mechanisms were lower for all 2D cultures compared to 3D cultures, and all small molecule inhibitors displayed higher composite efficacy in 3D cultures compared to 2D cultures.