Figure 2.

High‐risk prostate cancer shows increased expression of stromal vimentin (VIM) and reduced expression of stromal alpha‐smooth muscle actin (aSMA). A, Vimentin (VIM) and alpha‐smooth muscle actin (aSMA) expression (mean intensity) in full TMA cores, epithelium, and stroma of prostate cancer patients without cancer‐specific event (0) and with cancer‐specific event (1). Mann‐Whitney U test. B, Stromal expression of VIM and aSMA in tumors with Gleason score <7 (1), 7, (2), and >7 (3). Boxplot indicates minimum, first quartile, median, third quartile, and maximum. Individual data points indicate outliers (circle and asterisk). Kruskal‐Wallis H test. Cohort I (n = 115)