Table 1.
Hazard ratios (HR) in univariate and multivariate Cox Proportional Hazard regression analysis for prostate cancer‐specific mortality (PCSM) in Cohort I and Cohort II. HR for the different cell classes is reported as per 10% change in the proportion of the indicated cell class. Dx, diagnosis, Tx, treatment. Bolded P values remain significant after Benjamini‐Hochberg procedure. Wald test
| Univariate HR (CI, 95%) | P | n | Multivariate HR (CI, 95%) | P | n | |
|---|---|---|---|---|---|---|
| Cohort I | 113 | |||||
| Fibroblasts | 2.36 (1.68‐3.33) | 9.23E‐07 | 115 | 1.88 (1.30‐2.71) | .001 | |
| Smooth muscle | 0.39 (0.21‐0.71) | .002 | 115 | – | – | |
| Myofibroblasts | 5.45 (0.92‐32.2) | .061 | 115 | – | – | |
| Gleason score | ||||||
| <7 | 0 (0‐3.3E85) | .899 | 54 | 2E‐6 (0‐1.3E88) | .905 | |
| 7 | 0.15 (0.55‐0.42) | .00029 | 29 | 0.18 (0.06‐0.53) | .002 | |
| >7 | 1 | .0003 | 32 | 1 | .008 | |
| Age at Dx | 1.12 (1.07‐1.18) | .00003 | 117 | 1.04 (0.99‐1.09) | .136 | |
| Cohort II | 240 | |||||
| Fibroblasts | 1.89 (1.17‐3.01) | .009 | 248 | 1.73 (1.04‐2.86) | .034 | |
| Smooth muscle | 0.68 (0.50‐1.00) | .051 | 248 | – | – | |
| Myofibroblasts | 0.82 (0.54‐1.25) | .349 | 248 | – | – | |
| Gleason score | ||||||
| <7 | 0.15 (0.03‐0.70) | .016 | 64 | 0.21 (0.04‐1.04) | .056 | |
| 7 | 0.49 (0.20‐1.17) | .108 | 159 | 0.68 (0.27‐1.74) | .423 | |
| >7 | 1 | .042 | 37 | 1 | .161 | |
| Age at Tx | 1.04 (0.97‐1.11) | .239 | 269 | 1.03 (0.96‐1‐11) | .386 |
Abbreviation: CI, confidence interval
Bolded P values remain significant after Benjamini‐Hochberg procedure (P < 0.05).