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. 2019 Oct 24;12:144. doi: 10.1186/s12920-019-0602-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Illustration of SNP-CpG associations. (a) Methylation pattern of a nine-CpG DMR in FBN3. One SSc case was removed due to missing data. Methylation patterns exhibited a three-level stratification in this DMR where SSc cases were more prone to be hypomethylated. (b) Association between a C-to-A/G SNP at chr19:8138054 and significant loss of methylation in the DMR displayed in (a). (c) Methylation pattern of a three-CpG DMR in CDCA8. Methylation patterns exhibited a two-level stratification where SSc cases were more prone to be hypomethylated in this DMR. (d) Association between a G-to-A SNP at chr1:38156902 and significant increase in methylation in the DMR displayed in (c). Two SSc cases and one control with top three highest levels of methylation carried the A allele