Table 3.

Top five networks influenced by CpG differential methylation

Network	Molecules in Network	Score	Focus Molecules
Embryonic Development, Organismal Development, Reproductive System Development and Function	AGO2, AP2A2, BOP1, CACHD1, CENPS/CENPS-CORT, CEP120, Ck2, CSNK1D, CSNK1E, ESR1, FAAP20, FAM83D, FAN1, FBXW11, FGFR1OP, HPCAL1, Hsp70, INPP5B, KTN1, MAP3K9, mir-363, NIN, phosphatase, PPFIBP1, PSD4, RAPGEF5, RBM19, RNF166, Rnr, SAMD11, Smad2/3, Ubiquitin, UMODL1, USP2, WRAP73	52	29
Cancer, Connective Tissue Disorders, Organismal Injury and Abnormalities	Akt, ANKRD11, CEACAM3, CHIA, COL23A1, COL4A1, COL5A1, collagen, Dynamin, Eph Receptor, EPHA1, EPHA10, GNB1L, GTPase, HOOK2, JINK1/2, KIAA1217, KIF26B, KSR1, Laminin (family), LIMS1, MAGI1, MTORC2, NAV1, NCK, NCK2, PARVB, PBXIP1, PI3K p85, PRDM16, PTPRN2, RPTOR, SH3BP4, SH3PXD2B, SH3RF3	42	25
Cell Morphology, Cellular Assembly and Organization, Cellular Development	BCAR3, CK1, CLEC4C, DNAJC2, ERK1/2, Fgf, FXN, GALNT2, GSPT1, Hdac, HSP, HSPA12B, KCNN2, KCNN3, KCNQ3, LIN54, MARCH1, MHC Class II (complex), MYL12A, Ngf, NTF3, PLC gamma, potassium channel, Ral, RALGDS, ROBO1, ROR2, SH3BP2, SLC7A8, TFDP1, TUSC3, Vla-4, Wnt, WNT9A, histone deacetylase	35	22
Gene Expression, Connective Tissue Disorders, Immunological Disease	CBS/CBSL, Ctbp, CTBP2, ETV6, GATAD2B, GPC6, Growth hormone, HDAC4, HDL-cholesterol, hemoglobin, HIPK2, HISTONE, Histone h4, Immunoglobulin, Jnk, KCNJ6, LDL, LDL-cholesterol, MECP2, MTHFD1L, N-cor, NCOR2, NFATC1, NPC2, Nr1h, NTM, PF4, Pias, PON1, POU2F1, SBNO2, STAT5a/b, TTC39B, VSX1, ZBTB16	33	21
Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities	Alpha tubulin, ANO1, ATP11A, ATP5MC2, BETA TUBULIN, caspase, Cyclin E, DLGAP1, DLGAP2, DYSF, ERK, FMN1, FTSJ1, Hsp27, Hsp90, Insulin, KCNG2, MAP3K20, Mek, NLRP12, NNAT, p70 S6k, PACRG, PARP, Pde, PDE9A, PIWIL1, Ppp2c, PRKN, Proinsulin, RGPD4 (includes others), Sos, TRPV2, XAF1, ZBTB17	31	20