Table 4.

Top five diseases influenced by CHH differential methylation

Disease	Molecules related to Disease	FDR	Molecules
Familial skeletal dysplasia	ADAMTS2, DDR2, FAM20C, FDFT1, MYO18B, PDE4D, ROR2, TNFRSF11A	3.06E-07	8
Large intestine adenocarcinoma	ADAMTS2, AGT, ATXN3L, BAIAP2L1, CCDC155, CCDC85C, CFAP299, CMIP, CNNM2, CTDP1, DDR2, DNAJB13, FAM20C, FDFT1, FPR3, GAS7, GCM1, GRID2, IL13, IL27, IQCE, ITPK1, KCNJ12, KRT38, MCEE, MYO18B, NAV2, NDUFA10, NPHP4, PCSK6, PDE4D, PGS1, PITPNC1, PLEKHF1, PLEKHM3, PRKCA, PTPRN2, RALGPS2, RASA3, RIMBP2, RIN2, ROR2, RPS19, SLC30A1, SLC6A12, SPATS2L, SPG7, SV2C, TDRD5, TMEM92, TNFRSF11A, ZFYVE28	2.34E-06	52
Hereditary connective tissue disorder	ADAMTS2, AGT, CTDP1, DDR2, FAM20C, FDFT1, JDP2, MYO18B, PDE4D, RIN2, ROR2, TNFRSF11A	2.76E-06	12
Abdominal adenocarcinoma	ADAMTS2, AGT, ATXN3L, BAIAP2L1, CCDC155, CCDC85C, CFAP299, CMIP, CNNM2, CPNE6, CTDP1, DDR2, DNAJB13, FAM20C, FDFT1, FPR3, GAS7, GCM1, GRID2, IL13, IL27, IQCE, ITPK1, KCNJ12, KRT38, MCEE, MYO18B, NAV2, NDUFA10, NPHP4, PCSK6, PDE4D, PGS1, PITPNC1, PLEKHF1, PLEKHM3, PRKCA, PTPRN2, RALGPS2, RASA3, RIMBP2, RIN2, ROR2, RPS19, SLC30A1, SLC6A12, SPATS2L, SPG7, SSR1, SV2C, TDRD5, TMEM92, TNFRSF11A, ZFYVE28	8.89E-05	54
Liver carcinoma	ADAMTS2, AGT, CNNM2, CTDP1, DDR2, DNAJB13, FAM20C, FPR3, GAS7, GRID2, IL27, IQCE, JDP2, KCNJ12, MYO18B, NAV2, NDUFA10, NPHP4, PDE4D, PGS1, PITPNC1, PTPRN2, RALGPS2, RASA3, RIMBP2, RIN2, SLC30A1, SLC6A12, TDRD5, TNFRSF11A, ZFYVE28	2.32E-04	31