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. Author manuscript; available in PMC: 2019 Oct 25.
Published in final edited form as: Science. 2018 Nov 16;362(6416):799–804. doi: 10.1126/science.aas8961

Fig. 1. Important heterobiaryl-containing drugs and synthetic strategies.

Fig. 1.

(A) Heterobiaryls in drugs. (B) Heterobiaryls via metal-catalyzed cross-coupling reactions. R denotes a general organic group; Hal, halogen substituent. (C) Test system for heterobiaryl synthesis via phosphorus ligand coupling reactions. Ph, phenyl; Me, methyl; Et, ethyl; Tf, trifluoromethylsulfonyl; DBU, 1,8-diazabicyclo[5.4.0] undec-7-ene; rt, room temperature.