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. 2019 Oct 24;20:232. doi: 10.1186/s12931-019-1195-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Alterations in B-cell subsets in blood, LN and lungs of IPF patients. ((a) Representative gating strategy for identification of B-cell subsets in blood and single cell suspensions of lungs. Naïve B-cells (CD19⁺IgD⁺CD27-) IgD⁺ and IgD⁻ memory CD27⁺ B-cells, double negative (DN) B-cells (CD19⁺IgD⁻CD27⁻), transitional B-cells (CD19⁺CD24⁺CD38⁺), and plasmablast (CD19⁺CD38⁺CD27⁺) were identified. (b) c Percentage of circulating B-cell subsets of total B cells in HC (n = 21) and IPF patients (n = 27). (c) Proportion of B-cell subsets of total B-cells in single cell suspensions of control lungs (n = 9) and explanted IPF lungs (n = 11). Non-parametric two-tailed Mann-Whitney test was used. Data are expressed as mean and dots represent individual patient values. * P < 0.05 ** P < 0.01 *** P < 0.001