Table 4.
The Spearman correlation coefficients between on-target activity and six melting temperatures, four RNA fold scores, and four POSs
| Abbreviations | Features | Cas9 | eSpCas9 | Cas9 (△recA) |
|---|---|---|---|---|
| t1 | T(1_7) | -0.0302 | -0.0322 | — |
| t2 | T(8_15) | -0.0915 | -0.1304 | -0.0579 |
| t3 | T(16_20) | -0.1424 | -0.0695 | -0.0789 |
| t4 | T(1_20) | -0.1439 | -0.1346 | -0.0762 |
| t5 | T(-5_-1) | 0.0239 | 0.0385 | 0.0332 |
| t6 | T(21_+2) | 0.0098 | 0.0107 | 0.0119 |
| f1 | MFE | 0.0944 | 0.0895 | 0.0601 |
| f2 | FETE | 0.0862 | 0.0832 | 0.0517 |
| f3 | FMSE | -0.0246 | -0.0276 | -0.0323 |
| f4 | ED | 0.0166 | 0.0225 | 0.0286 |
| p1 | Cropit_POS | -0.1083 | -0.0998 | -0.0527 |
| p2 | Cctop_POS | -0.1088 | -0.1003 | -0.0518 |
| p3 | Mit_POS | -0.1130 | -0.1073 | -0.0607 |
| p4 | Cfd_POS | -0.1131 | -0.0985 | -0.0579 |
T(1_7) in Cas9 (△recA) scenario is not statistically significant