Table 4. TCGA univariable and multivariable Cox regression analysis.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age at diagnosis (≥60 vs. <60)	1.563 (1.166–2.096)	0.003*	1.199(0.839–1.714)	0.319
T stage (T3 + T4 vs. T1 + T2)	0.443(0 .316-0.622)	<0.000*	0.825(0.468–1.456)	0.507
N stage (N1–2 vs. N0)	0.517(0.380–0.703)	<0.000*	0.246(0.087–0.699)	0.008*
M stage (M1 vs. M0)	0.554(0.292–1.051)	0.071	0.616(0.218–1.741)	0.361
Clinical stage (III + IV vs. I + II)	0.543(0.399–0.738)	<0.000*	1.986(0.691–5.708)	0.203
Gender (Male vs. Female)	0.997(0.734–1.355)	0.986	1.040 (0.726–1.491)	0.830
Breslow depth value (≥3 mm vs. <3 mm)	0.370(0.265–0.518)	<0.000*	0.509(0.302–0.859)	0.011*
Five-miRNA signature (high risk vs. low risk)	0.613(0.456–0.823)	0.001*	0.605(0.424–0.863)	0.006*

Notes.

^*P < 0.05 was considered statistically significant.