Table 1.
List of genes regulated by thyroid hormones involved in their transport into the brain, mechanisms of tissue repair, and neuronal plasticity following ischemic stroke.
| Genes human/rodent | Gene name | Function | Tissue/cultured cells | References |
|---|---|---|---|---|
| SLC16A2/Slc16a2 | MCT8 | TH transport | Brain | (107) |
| DIO2/Dio2 | DIO2 | TH deiodination | ||
| DIO3/Dio3 | DIO3 | |||
| Bcl2 | Bcl2 | Neuronal survival, neurogenesis and neurotrophic factors | Brain cortex | (107–109) |
| Vegfa | VEGFA | |||
| Sox2 | SRY-box2 | |||
| Ntf | Neurotrophin | |||
| Nos2 | NOS2 | |||
| HIF2α | HIF2α | Neuroblastoma cell line | (107) | |
| VEGF | VEGF | |||
| c-JUN | c-Jun | |||
| ENO2 | Enolase-2 | |||
| Emx1 | empty spiracles homeobox 1 | mES cell line | (86) | |
| Tbr1 | T-box brain gene 1 | |||
| Bdnf | Brain derived neurotrophic factor | Hippocampal slices | (110) | |
| Slc12a5 | KCC2 | |||
| NRGN/Nrgn | Neurogranin | Synaptic plasticity | Hippocampus and forebrain/mES cell line | (86, 111–113) |
| CAMK4/Camk4 | Calmodulin kinase 4 | Brain/Neurons/mES cell line | (86, 114–117) | |
| Reln | Reelin | Brain | (118–120) | |
| Srg1 | Synaptotagmin-related gene 1 | Brain | (121) | |
| Nefh | Neurofilament heavy polypeptide | Neurons | (122) | |
| Nefm | Neurofilament medium polypeptide | (122) | ||
| GFAP | GFAP | Astrocytes | (123) | |
| Vim | Vimentin | Mesenchimal cells | (122) | |
| Nes | Nestin | Neurons | (86, 122) | |
| Vegf | VEGF | Angiogenesis | Brain | (124–126) |
| Angpt2 | Angiopoietin-2 |